A team of researchers from the Instituto Gulbenkian de Ciencia, Portugal, led by Miguel Soares, found that free heme, released from red blood cells during infection, the cause of organ failure is the lethal outcome of severe sepsis was. In addition, the team found that the toxic effect of free heme by hemopexin, a naturally occurring molecule that free heme can be overcome neutralized. These findings, published in the latest edition of the journal Science Translational Medicine , open the door to new ways of monitoring and possibly treatment of severe sepsis..
This can cause cells in several organs to die, lead to the dysfunction of multiple organs and eventually death. – Rasmus Larsen, first author of the study, explains: We have shown first, found a role for heme to a worsening organ injury during sepsis we that as heme in the blood accumulates, the levels of a hemopexin, a molecule that neutralizes the. Toxic effects of free heme decreases, what a path on check the the harmful effects of free heme. We started a very productive collaboration with Ann Smith (University of Missouri, hemopexin hemopexin for many years. Sent enough enough of this protein that we administer it to mice after they started developing severe sepsis. Continue reading