Bisphosphonates – osteoporosis medicines triple threat of bone necrosis A University of Uk Columbia and Vancouver Coastal Wellness Research Institute research has found that a favorite class of osteoporosis medicines nearly triples the chance of developing bone necrosis, a condition that may result in disfigurement and incapacitating discomfort haldol decanoate . The research may be the largest research of bone necrosis and bisphosphonates, a class of medications used by an incredible number of women worldwide to greatly help prevent bone fractures because of osteoporosis.