I3C is only one of many plant-derived chemicals, called phytochemicals, that Firestone can be investigating in his laboratory as potential anti-cancer agents. Among them is the anti-malarial medication artemisinin. Last month, the Journal of Biological Chemistry approved a paper by Firestone and his colleagues displaying that artemisinin blocks prostate malignancy cell growth by interfering with the same intracellular pathway as does I3C. This pathway involves the transcription factor SP1, which latches onto additional genes to boost their activity. ‘SP1 is actually a generalized focus on of phytochemicals,’ Firestone stated.Previous function had demonstrated that BACE2 may also lower beta-amyloid amounts by a second system: by reducing APP at a different place from BACE1. BACE2 cuts in the center of the beta-amyloid part, which prevents beta-amyloid creation. ‘The truth that BACE2 can lower beta-amyloid by two distinctive mechanisms makes this enzyme a particularly attractive applicant for gene therapy to take care of Alzheimer’s disease,’ says first author Samer Abdul-Hay, Ph.D., a neuroscientist at Mayo Clinic in Florida. The discovery shows that impairments in BACE2 might raise the threat of Alzheimer’s disease. That is important because particular drugs in clinical make use of – for instance, antiviral medications used to treat human being immunodeficiency virus – function by inhibiting enzymes much like BACE2.