An irregular dark lesion of latest onset Dermoscopy is particularly helpful in evaluating relatively little melanomas and may highlight regions of regression. Case presentation Over a six-month period, a 76-year-old man developed an irregular, deeply pigmented lesion on the medial aspect of his ideal calf . Dermoscopy showed a pigmented lesion that was asymmetrical and had an ill-defined border. The pigment network was broad and extremely irregular, associated with numerous dots and globules that ranged in color from light brownish to black. Excision biopsy demonstrated an atrophic epidermis with confluent proliferation of atypical melanocytes that were present as single cells and nests along the epidermal junction .The National Medications and Poisons Timetable Committee formulated the adjustments during meetings in June and October last year. Now pharmacists will become keeping a close view on the sale of the drugs without one allowed to buy more than a five-day supply. The dose of codeine in the preparation will be reduced to a maximum of 12 milligrams each day also. Earlier patients could purchase packs of 96 tablets but now they would be able to purchase 30 tablets in a six each day pack and 40 tablets within an eight per day pack. The National Medicines and Poisons Schedule Committee has brought the fact that one in 20 forth, 000 people abuse mixture analgesics containing codeine and ibuprofen, which can trigger perforated gastric ulcers, bleeding from these stomach ulcers, liver damage, kidney failure and actually deaths.