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Despite the fact that almost all diseases could be traced to a defect in how cells react to signals, little is known about how exactly signalling pathways are managed in regular cells and the adjustments that occur in abnormal conditions. Using the Andor Revolution XD Confocal Microscope for live cell studies, Prof. Puthenveedu offers led a global team of experts to elucidate how signalling receptors are recycled to the cell membrane. The discovery of the mechanism where signalling receptors travel back to the top of cell after activation and internalisation opens up a new class of therapeutic targets.