‘Acquiring cancer-specific alterations in the blood may help clinicians monitor patients for relapse and determine whether residual cancer tumor cells remain in your body after medical procedures,’ says Mark Sausen, a Johns Hopkins graduate pupil and among the lead scientists involved in the extensive research. The Johns Hopkins-CHOP team plans to conduct further studies in larger groups of patients to verify the ARID1A-ARID1B correlation to prognosis.. Children with changes in bully genes have poor survival In a genome sequencing research of 74 neuroblastoma tumors in children, researchers at the Johns Hopkins Kimmel Cancer Center and the Children's Medical center of Philadelphia discovered that patients with changes in two genes, ARID1A and ARID1B, survive only 25 percent as long as sufferers without the changes.However the medication was relabeled in 2004 to warn of a rare, serious side effect involving low blood circulation pressure. Zelnorm, too, has been associated with rare circumstances of ischemic colitis, but there is little evidence that the medicine causes the problem. However as much as 70 percent of sufferers have tried the various medications and less than half are happy. A third medication, lubiprostone , was granted authorization in January for the treating chronic constipation in adults and it appears to be safe and effective.