What happened? The volume of pedicardial fat fell – from 39 milliliters to 31 milliliters significantly. At the same time, the so-called E/A ratio, a common way of measuring cardiac function, rose from 0.96 to at least one 1.2. And body mass index , an indicator of surplus fat, fell from 35.3 to 27.5. A BMI of 30 or more indicates weight problems, while a BMI of 25 to 29.9 indicates overweight, based on the website of the National Cardiovascular Blood and Lung Institute. The BMI of regular pounds people ranges from 18.5 to 24.9. Perhaps most striking, all of the volunteers were able to discontinue their insulin injections after getting into calorie restriction, study writer Dr Sebastiaan Hammer of the division of radiology at Leiden University Medical Center told Medscape.